Enteric nervous system manifestations of neurodegenerative disease

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The enteric nervous system.

T HE enteric nervous system is a collection of neu-rons in the gastrointestinal tract 1 that constitutes the " brain of the gut " and can function independently of the central nervous system. 2 This system controls the motility, 3,4 exocrine and endocrine secretions, 5 and microcirculation 6 of the gastrointestinal tract; it is also involved in regulating immune and inflammatory processes. 7 In...

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The human enteric nervous system.

Decades of work in animal models have demonstrated that the enteric nervous system (ENS) plays a key role in controlling gut functions. Recent advances made it possible to extend such studies to the ENS of man in health and even in disease. Such studies have already provided new insights into the pathophysiology of inflammatory and possibly functional bowel diseases. Studies on human ENS reveal...

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Lewy bodies in the enteric nervous system in Parkinson's disease.

We systematically studied the intramural nervous system of the alimentary tract in patients with Parkinson's disease and found that Lewy bodies were distributed widely in the Auerbach's and Meissner's plexuses. In the central nervous system, we recognized a striking similarity between the distribution of Lewy bodies and that of monoaminergic neurons. More recently, we have demonstrated that neu...

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Enteric nervous system development: migration, differentiation, and disease

The enteric nervous system (ENS) provides the intrinsic innervation of the bowel and is the most neurochemically diverse branch of the peripheral nervous system, consisting of two layers of ganglia and fibers encircling the gastrointestinal tract. The ENS is vital for life and is capable of autonomous regulation of motility and secretion. Developmental studies in model organisms and genetic stu...

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Nervous manifestations in Eales's disease.

IN 1880 and again in 1882 Henry Eales of Birmingham described the clinical picture of primary recurrent retinal haemorrhage in young adults. His seven cases were all young men, whose ages ranged from 14 to 29. They had in common a history of headache, epistaxis, variations in peripheral circulation, dyspepsia, and chronic constipation. One was diagnosed as having mitral incompetence, and in two...

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ژورنال

عنوان ژورنال: Brain Research

سال: 2018

ISSN: 0006-8993

DOI: 10.1016/j.brainres.2018.01.011